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Compared
PDRN went from a clinic injection to one of the most wanted serum ingredients of the year. The jars are not all the same, and the labels tell you more than the marketing does.
Quick answer. There is no single best PDRN serum, but some are far better labeled than others. Of the 16 popular PDRN serums and creams we compared on 26 October 2026, 7 state no PDRN amount on their US listing, and the figures the others print measure different things, from 1,200 ppm of salmon DNA to 100,000 ppm of a branded ginseng ingredient. On intact skin, every one of them works mainly as a hydration step, because PDRN is far larger than what skin lets through on its own. If you want PDRN past the surface at home, a micro-infusion kit such as our MicroInfuser is the different tool for that job.
None of the jars in this comparison can open the skin's outer barrier. The EvenSkyn MicroInfuser does it with a sterile, single-use 0.5 mm needle head and a sealed 5 mL ampoule of Syntha-Pep, our biosynthetic PDRN serum at a published 2,000 ppm, once every two weeks. It costs more than any jar here, because you are paying for the delivery as well as the serum.
See the MicroInfuser · $119.99 USDWe read the US listing for each product on 26 October 2026: the brand's own US store where one exists, otherwise Ulta, Sephora or Amazon. The table records what each brand states about its PDRN, what it costs per mL and whether fragrance or essential oils are listed. It does not rank results, because nobody has tested these products against each other. Where a brand does not state something, the table says so.
| Product | Format and size | Price (USD) | Price per mL | PDRN source, as the brand states it | PDRN amount, as the brand states it | Fragrance or essential oil listed | Worth knowing |
|---|---|---|---|---|---|---|---|
| Medicube PDRN Pink Peptide Serum | Serum, 30 mL | $24.00 USD, was $26.00 USD (brand site) | $0.80 USD | Salmon DNA, or “Rose PDRN (Vegan)” in a second version | Not stated on medicube.us. UK retailer Beauty Bay lists 10,000 ppm | Yes, fragrance | Sodium DNA 8th of 40 (salmon version), 30th of 38 (rose version) |
| Medicube PDRN Pink Peptide Cream | Cream, 1.69 fl oz (about 50 mL) | $22.90 USD (Ulta) | $0.46 USD | Salmon PDRN | Not stated | Yes, fragrance | Sodium DNA 29th of 58 |
| Anua PDRN Hyaluronic Acid Capsule 100 Serum | Serum, 30 mL | $28.00 USD (brand site) | $0.93 USD | Salmon DNA | Not stated. The “100” is not explained | None listed | Sodium DNA 21st of 34 |
| Anua PDRN Hyaluronic Acid 100 Moisturizing Cream | Cream, 60 mL | $24.00 USD (Ulta); $31.00 USD (brand site) | $0.40 USD to $0.52 USD | Salmon DNA | Not stated. The “100” is not explained | None listed | Sodium DNA 10th of 48 on anua.com, 7th on Ulta's list |
| VT PDRN Essence 100 | Essence, 30 mL | $28.00 USD (Ulta) | $0.93 USD | Wild ginseng (plant) | 100,000 ppm of PHYTO PDRN Panax, VT's branded ingredient | None listed | Sodium DNA last, 31st of 31 |
| VT PDRN Cream 100 | Cream, 1.69 fl oz (about 50 mL) | $26.00 USD (Ulta) | $0.52 USD | Wild ginseng (plant) | 100,000 ppm of PHYTO PDRN Panax | None listed | Sodium DNA 62nd of 71 |
| VT PDRN Capsule Cream 100 | Gel cream, 50 mL | $20.00 USD (Ulta) | $0.40 USD | Wild ginseng (plant) | 100,000 ppm of PHYTO PDRN Panax | None listed | Sodium DNA 46th of 67 |
| COSRX 5 PDRN Collagen Intense Vitalizing Serum | Serum, 3.38 fl oz (about 100 mL) | $17.50 USD on sale, regular $25.00 USD (Ulta) | $0.18 USD on sale | Five sources: salmon, centella, green caviar, rice and lactobacillus | Not stated | None listed | Sodium DNA 10th and Hydrolyzed DNA 29th of 38. “Clinically proven” claim with no study details on the page |
| Dr.Reju-All Advanced PDRN Rejuvenating Cream | Cream, 20 mL | $29.90 USD, was $56.47 USD (brand site) | $1.50 USD | “99% pure salmon DNA extract” | 1,200 ppm (0.12%). The 99% is purity, not amount | None listed | Sodium DNA 19th of 29 |
| REJURAN Turnover Ampoule | Ampoule, 30 mL, syringe dispenser | $52.00 USD (brand site; same at Sephora) | $1.73 USD | c-PDRN from “sustainably sourced salmon DNA” | 0.5% in Sephora's product title, not explained on REJURAN's page | None listed | Hydrolyzed DNA 12th of 24. Clinical claim cites 22 people |
| Medik8 Exo-PDRN Prismatic+ | Serum, 30 mL | $96.00 USD (brand site) | $3.20 USD | “Vegan Prismatic PDRN”, made by microbes | Not stated. Brand gives a molecular weight of 81.9 kDa | None listed; brand says fragrance-free | “DNA” 7th of 41. Clinical claim cites 60 volunteers over 8 weeks |
| Dr. Althea PDRN Reju 2000, 5000 and 10000 Creams | Creams, 20 g each | 2000: $20.90 USD (Ulta). 5000: $29.00 USD (Ulta). 10000: $24.43 USD on sale from $34.90 USD (Amazon) | $1.05 USD, $1.45 USD and $1.22 USD per g | 2000 and 10000: salmon. 5000: “Vegan Biome PDRN” | 2,000, 5,000 and 10,000 ppm, confirmed by the brand as ppm of PDRN | None listed | Sodium DNA 15th of 46, 14th of 34 and 11th of 52 |
| Centellian24 360 Shot PDRN Active Serum | Serum, 50 mL | $36.10 USD, was $38.00 USD (brand site) | $0.72 USD | Not stated on the product page | Not stated. “360” is not explained as an amount | Yes: fragrance, limonene and rose flower oil | Sodium DNA 17th of 46 |
| The INKEY List PDRN Serum | Serum, 30 mL | $18.00 USD (brand site) | $0.60 USD | Plant, from Artemisia capillaris (“vegan PDRN”) | 20,000 ppm (2%) of INJIN PDRN, a supplier's trade ingredient | None listed | Hydrolyzed DNA last, 20th of 20. Leaving INKEY's own site; still sold on Amazon |
| EvenSkyn MicroInfuser kit with Syntha-Pep (ours) | 4 sealed 5 mL ampoules plus 4 sterile, single-use 0.5 mm needle heads | $119.99 USD (our site), $30.00 USD per session | $6.00 USD, heads included | Biosynthetic, not derived from salmon | 0.2% (2,000 ppm), per the supplier's documents | Yes, a trace of bitter orange flower oil, an essential oil | PDRN 9th of 32. Raw material measured 31 kD on average. Batch and test data |
Five checks tell you most of what a PDRN product is. None of them needs a lab.
Tap the number your product uses. You get the percentage, roughly how much PDRN a 30 mL bottle would hold at that level, and what the number cannot tell you. Amounts assume a water-based formula that weighs about 1 g per mL.
This is the level we publish for Syntha-Pep, so each 5 mL ampoule holds roughly 10 mg of PDRN, and the level Dr. Althea states for its PDRN Reju 2000 Cream. What no ppm figure can tell you is how much of the PDRN reaches living skin.
A “100” in a product name is not always a concentration. Anua never explains the 100 in its names, and VT pairs its 100 with a figure of 100,000 ppm for a branded ingredient. If a brand confirms a figure means 100 ppm of PDRN, that is a small amount, about one twentieth of a 2,000 ppm formula.
Dr. Althea states this level for its PDRN Reju 5000 Cream, and Sephora titles the REJURAN Turnover Ampoule at 0.5%. Check that a figure like this is stated in ppm, not just printed in the name, and whether it refers to pure PDRN or to the PDRN ingredient as supplied, which can itself be a dilute solution.
Dr. Althea states this level for salmon PDRN in its PDRN Reju 10000 Cream. At 1%, the PDRN sits right at the line where ingredient lists stop being in strict order. If it shows up at the bottom of a long list, ask what the figure measures.
The INKEY List states 20,000 ppm (2%) of INJIN PDRN, a supplier's trade ingredient, and lists Hydrolyzed DNA last of 20. Two percent would be a high level of pure PDRN. Above 1%, the ingredient should appear in the ordered part of the list, so a 2% claim with the DNA listed last is worth a question to the brand: does the figure mean pure PDRN, or the PDRN raw material?
No number means no disclosure. Medicube's US page, Anua, COSRX, Medik8 and Centellian24 state no PDRN amount. That does not make them bad products. It means the PDRN claim is a story you cannot check, so choose on the rest of the formula, the price and how your skin likes it.
The format decides where a PDRN product does its work far more than the brand on the box. A serum or cream on intact skin works at the surface. Getting past the outer barrier takes either micro-channels or a needle in a clinic.
| Format | What it does well | Where the PDRN sits | Best for | Watch for |
|---|---|---|---|---|
| Serum or essence | Light, layers under moisturizer, daily use | On the surface of intact skin | A daily hydration and glow step | Fragrance, and amounts that are not disclosed |
| Cream | Holds moisture in, comforting at night | On the surface of intact skin | Dry or mature skin as the last step | A richer texture that oily skin may not like |
| Ampoule | Concentrated, often single-use | On the surface, unless used with micro-channels | Short courses, or a kit built for needles | A multi-use bottle is not packed for open channels |
| Micro-infusion kit (ours: MicroInfuser) | Sealed serum applied through sterile 0.5 mm needles | Through temporary channels in the outer barrier | PDRN past the surface at home, once every two weeks | Not for everyone: read the contraindications |
| Clinic injection (PDRN or PN) | Placed in the dermis by a clinician | In the dermis | The strongest evidence base | Cost, injection risks and downtime |
Swipe the diagram sideways to see all three formats.
It cannot do what the injection studies did. Most of the evidence behind PDRN comes from pharmaceutical-grade salmon PDRN that was injected or applied to wounds, where it acts on adenosine A2A receptors involved in tissue repair[1]. A cosmetic on intact skin is a different route and, often, a different material.
It mostly stays on top. PDRN in the clinical literature weighs 50,000 to 1,500,000 daltons[1], against a rough 500-dalton limit for molecules crossing intact skin on their own[2]. We found no published measurement of how much PDRN from a serum or cream reaches living skin. A 2026 dermatology review says topical PDRN and PN may have limited penetration and are less effective than injections, and that topicals “may be useful as maintenance treatments and in improving skin hydration”[6].
So buy a jar for what a jar does. Expect the look of hydrated, smoother, more comfortable skin. Do not expect lifting, filling or injection-style change from a topical.
Micro-channels change the route, not the honesty rules. In a lab study on human skin, microneedle pretreatment raised the delivery of small cosmetic peptides that otherwise struggle to get in[7]. That is the reason micro-infusion exists. Nobody has measured exactly where PDRN goes after a 0.5 mm stamp, though. And our own PDRN is smaller than the material in the injection studies: its raw material measured 31 kD on average[8], so we do not borrow those results for it.
The EvenSkyn MicroInfuser kit holds four sterile, single-use 0.5 mm needle heads and four sealed 5 mL ampoules of Syntha-Pep, our biosynthetic PDRN serum at 2,000 ppm (0.2%), with sh-Oligopeptide-1 (EGF) and Copper Tripeptide-1 (GHK-Cu). One evening session every two weeks, about 5 to 10 minutes. $119.99 USD per kit when we checked on 26 October 2026, which is $30.00 USD per treatment, with a 60-day money-back guarantee on unused treatments, counted from delivery.
See the MicroInfuser · $119.99 USDIt depends on the job, because nobody has tested these products against each other. For the highest stated amount, Dr. Althea PDRN Reju 10000 Cream states 10,000 ppm of salmon PDRN. For the lowest price per mL, COSRX 5 PDRN Collagen Intense Vitalizing Serum was $17.50 USD for about 100 mL on sale at Ulta on 26 October 2026. For plant-based PDRN, VT PDRN Essence 100, or Medik8 Exo-PDRN Prismatic+ at the premium end. For PDRN past the skin's surface at home, a micro-infusion kit such as the EvenSkyn MicroInfuser, which we make.
Korean brands make most of the PDRN products on US shelves, including Medicube, Anua, VT, COSRX, REJURAN, Dr. Althea and Centellian24. Choose by what you can check: Dr. Althea states a ppm figure for each of its PDRN Reju creams, VT states one for its ginseng-based ingredient, and REJURAN shares its name with the polynucleotide injections sold to clinics. On intact skin, all of them work mainly as hydrating steps.
Look for a figure with a unit, in ppm or percent, then find the PDRN on the ingredient list under a name such as Sodium DNA, Hydrolyzed DNA or Polydeoxyribonucleotide. 10,000 ppm is 1%. On US labels, ingredients above 1% must be listed in descending order, so a claim above 1% should sit in the ordered part of the list. A number printed in the product name is not a disclosure until the brand says what it measures.
Only sometimes the amount. Dr. Althea confirms that the 2000, 5000 and 10000 in its PDRN Reju creams are ppm of PDRN. VT names its products 100 and states 100,000 ppm of its PHYTO PDRN Panax ingredient, but never says the name refers to it. Anua never explains its 100, and the 360 in Centellian24's 360 Shot is not explained as an amount. Treat a number as a name until the brand says what it measures.
Salmon and trout PDRN is the material behind most of the clinical research, where it was injected or used on wounds and acts on adenosine A2A receptors involved in tissue repair. In a serum or cream on intact skin, treat it as a hydrating, comforting ingredient: a 2026 dermatology review says topicals may have limited penetration and may be useful for maintenance and skin hydration. If you are allergic to fish or shellfish, ask your doctor before using any PDRN product.
Not necessarily. Plant PDRN is DNA from a different source, such as ginseng, and a 2026 review notes that plant DNA preparations may differ from salmon PDRN in molecular weight and fragment length. The published research on plant PDRN is early: a 2023 study of ginseng-root PDRN tested skin cells and lab-grown skin models, with no human trial. Salmon PDRN has the longer clinical record, mostly as an injection. A vegan label tells you the source, not the strength or how much is in the bottle.
Pick by texture and routine. A serum is light and layers under moisturizer, so it suits oily and combination skin and morning routines; follow it with your usual moisturizer, and sunscreen in the morning. A cream holds moisture in and can stand in as your moisturizer at night, which suits dry or mature skin. Neither format changes the basic limit: on intact skin, most of the PDRN stays at the surface.
They are different ingredients. PDRN is purified DNA fragments, traditionally from salmon or trout sperm, and most of its research is on injections and wound healing. Exosomes are tiny vesicles that cells release to carry signals, and skincare versions are commonly sourced from plants or from cell-culture fluid. Some 2026 products combine the two, which tells you nothing about how much of either is inside.
For serums and creams on intact skin, most people can. PDRN is not an acid or an exfoliant. Add one new product at a time, and if your skin is sensitive, use them on alternate nights. Micro-infusion is different: pause retinoids, AHAs, BHAs and vitamin C for roughly 48 to 72 hours around a session.
Yes, most are made for it. Medicube, Anua, VT, COSRX, REJURAN and Medik8 all give morning-and-evening directions, so follow the brand's own. Micro-infusion is not a daily step: the MicroInfuser's standard cadence is one evening session every two weeks, and never more often than once every ten days.
No. Injections place polynucleotides in the dermis, under the skin's outer barrier. A serum or cream works mostly at the surface, so expect the look of hydrated, smoother skin, not injection-style change. Micro-infusion sits between the two: it opens temporary channels through the outer barrier at home, but it is not an injection either.
Not a bottle you have been opening and touching for weeks. Anything applied through micro-channels should be made and packed for that use: sealed, single-use and formulated for it. Fragrance materials, including essential oils, deserve a second look before they go into a channel, and that includes the trace of bitter orange flower oil in our own Syntha-Pep, which we disclose. Our PDRN serum checker walks through the tests.
If you want an affordable, glowy daily serum and fragrance does not bother you, it is a reasonable buy at $24.00 USD for 30 mL on medicube.us (26 October 2026), sold in salmon and rose (vegan) PDRN versions. Its US page states no PDRN amount and fragrance is on the ingredient list, so reactive skin may do better with an option with no fragrance listed, such as the Anua or VT serums. Like any multi-use bottle, it is not made for micro-channels.
PDRN serums are usually light, water-based formulas, but the rest of the formula decides how acne-prone skin reacts. Choose a lighter serum over a rich cream, patch test first, and never micro-infuse over active inflamed acne, open lesions or broken skin.
Safety data for many active skincare ingredients in pregnancy is limited. Ask your obstetrician or dermatologist before starting any PDRN product, and before any micro-infusion.
No. Syntha-Pep, the serum sealed in each MicroInfuser ampoule, uses PDRN of biosynthetic origin, not derived from salmon, at 0.2% (2,000 ppm), alongside sh-Oligopeptide-1 (EGF) and Copper Tripeptide-1 (GHK-Cu). It contains a trace of bitter orange flower oil, an essential oil, which we list. A kit is $119.99 USD for four sessions (read 26 October 2026).
We read each product's own page, or a major US retailer's listing where the brand does not sell directly in the US, on 26 October 2026, and recorded the price, size, stated PDRN source, stated PDRN amount and the published ingredient list. Where a brand does not publish a figure, the table says not stated rather than estimating one. Where two US listings disagree, as with the Anua cream and REJURAN, the table uses the brand's own list and notes the other.
We did not test these products on skin, run a panel, or receive any of them for free, and we earn nothing from any competitor mention. EvenSkyn makes the MicroInfuser and Syntha-Pep, and those rows are marked as ours. Prices change with promotions, so check the live listing before you buy.
Related reading: does topical PDRN get into skin, the PDRN serum checker for serums used with needles, how to use PDRN at home, and the salmon DNA facial, at home vs clinic.
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