anti aging

Electrical Stimulation and Fibroblast Migration: Unraveling the Wound Healing Process

Electrical Stimulation and Fibroblast Migration: Unraveling the Wound Healing Process

Wound healing is a natural dynamic process, and we seldom think about it. The process occurs in our bodies every day, the moment there's an impact. Understanding how the cells, tissue, and collagen are involved in this process may be a key to knowing how to increase wound healing. 

This may also be applicable in rejuvenating skin and anti-aging. As we know, aging is a major factor that impacts regenerative capacity and wound healing. Therefore, methods that promote skin healing may help. 

One way to achieve this may be electrical stimulation of fibroblast migration. Simply put, there's evidence of collagen forming and quick wound healing by applying microcurrents. As a result, microcurrent facial devices are gaining popularity for various benefits. Keep reading to learn more!

Understanding Wounds and the Importance of Quick Healing Process

Wound healing refers to the healing of the different layers of the skin. It begins with the epidermal layer with cellular, molecular, and humoral healing processes. A wound on the skin goes through inflammation at first, followed by proliferation and remodeling. 

Caring for wounds promotes healing without any risk of infection due to bacteria. Different types of wounds may range from closed wounds and open wounds. In simple terms, a bruise may classify as a closed wound. On the other hand, cuts on the skin, active acne, and burns classify as open wounds. 

One way to promote quick wound healing is via electrical stimulation and fibroblast migration. Learn more about how these two processes work. 

What is Fibroblast Migration?

The basic function of fibroblast is to work as a connective tissue for tissues and organs in the body. Fibroblast migration is the formation of granulation tissue in wounds. The monocytes, platelets, and other blood constituents release peptide factors triggering the fibroblast migration to increase wound healing. 

This helps reconstitute the skin at the wound site on the skin. The wound tissue regenerates during this process so that healing can be started. 

When it comes to wounds on the skin, dermal fibroblasts use lipopolysaccharide for migration, followed by wound healing. Fibroblasts secrete type I or type III collagen proteins to aid in the structural framework of the tissues. The motile function of fibroblasts makes them capable of tissue homeostasis and wound repair in the body. 

Understanding Electrical Stimulation for Wound Healing

Electrical Stimulation (ES) is the application of electrical current to the skin using electrodes close to the wound surface. The electric currents stimulate fibroblasts for wound healing. It has applications in healing chronic skin wounds and regenerating cells. 

As you read about the motile function of fibroblast, electrical stimulation is proven to enhance dermal fibroblast activity to promote wound healing. In a study, normal human fibroblasts were kept in heparin-bioactivated conductive membranes. They were cultured for 24 hours; after this, the fibroblast was exposed to ES of 50 or 200 mV/mm for 2, 4, or 6 hours.

These cells were studied for healing capacity. As observed, electrically stimulated cells were more viable after 6 hours than unexposed ones. ES helped in producing FGF-1 and FGF-2 to add more cell growth. 

Moreover, electrically stimulated dermal fibroblasts migrated quicker and gravitated towards the collagen gel matrix. This fibroblast growth continued to reach the myofibroblasts stage even after stopping the stimulation. 

With the rapid conversion of fibroblasts to myofibroblasts, there was quick wound healing. The same method may be applied to improve the health of the skin and muscles underneath. 

Using an EMS Tool for Youthful Skin

The EMS tool is an advanced EMS beauty gadget that utilizes a mild electric current to stimulate skin activity and muscle contractions. Encouraging collagen and elastin production, it tightens and tones the skin. Moreover, this helps in reducing sagging and minimizing wrinkles. 

This physical and electrical energy combination supports the facial structure, resulting in a more youthful complexion. The gadget's versatility offers virtually instant beneficial effects for users of all ages, making it an effective and popular choice for enhancing skin appearance and promoting cellular renewal.

You may choose EvenSkyn® Phoenix: Premium Face Lifting Microcurrent Bar, combining technologies like microcurrent, derma rolling, and deep kneading mechanical massaging. Use it for five to ten minutes on your neck every day. 

The massaging action from four alloy rollers at a 115° angle may help you reduce the puffiness of your face. Meanwhile, the microcurrent may work to improve blood circulation in the skin. This will promote healthy skin texture and firmness. 

Effect of Electrical Stimulation on Skin

EMS has been found to promote faster and more efficient wound healing. When applied to the affected area, the electrical impulses stimulate the production of collagen, a vital protein responsible for tissue repair and regeneration. 

The increased collagen synthesis accelerates the healing process, reducing the appearance of scars, lines and ensuring a smoother complexion.

Natural Lifting Effect

One of the most sought-after benefits of using EMS tools for skin care is its natural lifting effect. The microcurrents generated by the EMS device penetrate deep into the skin's surface, stimulating the facial muscles. This, in turn, tones and firms the skin, resulting in a more lifted and contoured appearance. With consistent use, individuals may notice a visible improvement in facial contours, achieving a youthful and rejuvenated look.

Increase in Blood Flow

EMS therapy also enhances blood circulation beneath the skin's surface. Improved blood flow ensures better nutrient and oxygen delivery to the skin cells, promoting cellular rejuvenation. As a result, the skin may appear more vibrant, with a healthy glow that radiates from within. Furthermore, the increased blood flow aids in flushing out toxins, contributing to a clearer and more radiant complexion.

Muscle Toning

EMS tools may also be used to tone facial muscles, especially the jawline and cheekbone. The electrical impulses target specific muscle groups, stimulating them to contract and relax. This action may strengthen the facial muscles, supporting the skin's structure better. As a result, the skin appears firmer, and the signs of sagging and fine lines are visibly reduced.

Wrapping Up

The human body is magical, as seen in how relentless it is in wound healing. Considering the above study and the power of science, microcurrent facials may lead to skin rejuvenation. Hence proving electricity isn't just for powering our gadgets! 

The dynamic duo of electrical stimulation and fibroblast migration has been unveiled to be wound-healing. You may get firmer skin by diminishing sagginess and lifeless skin using microcurrent.

In conjunction with traditional skincare routines, EMS tools may be beneficial to tighten the skin like never before! Who knew a little electric current might give you that natural facial lifting effect? 


Mahmoud Rouabhia, Hyunjin Park, Shiyun Meng, Habib Derbali, and Ze Zhang. "Electrical Stimulation Promotes Wound Healing by Enhancing Dermal Fibroblast Activity and Promoting Myofibroblast Transdifferentiation" 2013

Atieh Abedin-Do, Ze Zhang, Yvan Douville, Mireille Méthot, Julien Bernatchez, Mahmoud Rouabhia. "Electrical stimulation promotes the wound-healing properties of diabetic human skin fibroblasts" 2022

Cen Chen, Xue Bai, Yahui Ding & In-Seop Lee. "Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering" 2019

Sarah Snyder, Carlisle DeJulius & Rebecca Kuntz Willits." Electrical Stimulation Increases Random Migration of Human Dermal Fibroblasts" 2017

Holly N. Wilkinson and Matthew J. Hardman. "Wound healing: cellular mechanisms and pathological outcomes" 2020

Xiaolei Ding, Parisa Kakanj, Maria Leptin, Sabine A. Eming. "Regulation of the Wound Healing Response during Aging" 2021

Drishtant Singh, Vikrant Rai, and Devendra K Agrawal. "Regulation of Collagen I and Collagen III in Tissue Injury and Regeneration" 2023

Hani Yousef; Mandy Alhajj; Sandeep Sharma. "Anatomy, Skin (Integument), Epidermis" 2022

Marta A Kisiel, Agnes S Klar. "Isolation and Culture of Human Dermal Fibroblasts" 2019

Aisha Farhana; Yusuf S. Khan.”Biochemistry, Lipopolysaccharide" 2023

Xinkai Xu, Han Zhang, Yan Yan, Jianru Wang, Liang Guo. "Effects of electrical stimulation on skin surface" 2021

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Electrodermal Stimulation: The Science of Microcurrent Therapy and its Effects on facial muscles
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