anti aging

Transcriptomics and Skin Tightening: Gene Expression Profiling of Microcurrent Effects

Transcriptomics and Skin Tightening: Gene Expression Profiling of Microcurrent Effects

With technological advancement and various studies, skin tightening isn't rocket science. However, you may want to learn what goes into deep layers of your skin and how modern treatments work to rejuvenate the skin, fighting aging signs. Knowing before investing in fancy microcurrent or radio frequency devices is essential. 

These devices are proving effective in the skincare department with the power of science behind them. The first signs of aging may appear in fine lines, sun spots, and mild wrinkles. These signs may impact your skin's appearance, causing it to sag and lose its vibrancy. You may want to combat these signs before they progress and become permanent. 

As skin tightening works at a cellular and muscular level, a device targeting both may be an ideal choice. We are talking about microcurrent facials here. Microcurrent is known to be a non-invasive workout for your facial muscles to promote skin tightening. Keep reading to learn more behind the scenes and how to achieve flawless skin. 

Do Genes Play a Role in Skin Health

Skin aging and overall health depend on both lifestyle and genetic makeup. We all know how complex skin can be considering environmental factors such as the sun's UV rays, skincare regime, age, genetics, and lifestyle choices like smoking and drinking. Other influencing factors may be geographical location, race, and gender. 

As a result, a custom approach is needed to target aging and skin health for everyone. Genes that determine the melanin level in the skin do more than just give color to the skin. It also protects from sun damage and other signs of aging. More melanin in the skin delays aging by 10-20 years, hence preventing any early signs of aging in the skin. Moreover, compared to less melanin skin, it has better wound healing and collagen production.

Transcriptomics Studies for Fibroblasts Age

Collagen is known to be the building block for the skin and keeps it together to appear tight. Fibroblasts present in the skin are responsible for secreting collagen proteins. The collagen matrix formed by fibroblasts creates the basic structural part of connective tissues in the dermis. Another function of fibroblasts is to repair the skin, ensuring wound healing.

Many studies are conducted to understand how the skin works at a cellular level. This significantly helps in developing technology to promote healthier-looking skin. In one study, Scientists used a single-cell RNA sequencing method to analyze transcriptomes. The sample was collected from a sun-protected area in healthy human donors. 

The experiment included transcriptomes of more than 5,000 fibroblasts. Their results were in favor of fibroblast priming reduction with age. Aging is also responsible for reduced interaction between skin cells and dermal fibroblasts. 

Hence, it proves how skin changes can be rectified with various methods. This groundbreaking study directly impacts human skin health and the phenotypes involved in doing so. 

Truth Behind Microcurrent Treatment on Skin

Before delving into the new trend of microcurrent treatment, you may wish to know the science behind it. Not only is it practical, it's also a nonsurgical facial treatment. It may be safer if you wish to get similar anti-aging benefits minus the side effects of a surgical facelift

Microcurrent was studied for its efficacy in skin renewal and diminishing wrinkles. In a clinical trial, thirty women up to 45 years of age with wrinkles were treated with microcurrent on the face. 

This experiment was done for twenty minutes every day for thirty consecutive days. The results were compared using photos taken before and after the trial. Further, the photos were studied by blinded reviewers to ensure unbiased judgment. 

Another key determining component was the self-assessment of the before and after. There were positive results considering the appearance of wrinkles and spots on the skin on the forehead reduced to 18.37%. Microcurrent also helped to combat aging signs in the nose and mouth by 7.61% in the first step and 5.85%. 

The results stayed the same even after a month of treatment. Moreover, there was a significant improvement in the skin's texture and overall recovery. Lastly, 70% of participants were satisfied with the treatment results. 

Benefits of Microcurrent Facials

Here are some ways microcurrent facials may rejuvenate your face:

Workout your facial muscles

The human face has over two dozen individual muscles on each side. Microcurrent works as a mini workout for these muscles helping them to stay lifted and in shape. Moreover, it creates collagen, the building block for these muscles. Hence, giving your skin a tight and supple feel.

Better blood circulation

More blood will come up to the skin's surface, increasing circulation in the application area. As a result, this will target the dullness in the skin and may add a plump appearance.

Skin inflammation reduction

The active delivery of microcurrent may promote oxygen into the facial tissues. Furthermore, these cells may receive more nutrients, leading to reduced inflammation in the skin.

Quicker healing

With more ATP(adenosine triphosphate) synthesis, microcurrent promotes mitochondrial functions, thus, leading to quicker wound healing. ATP release also aids in moisture retention in the skin and soothes wounds. 

Optimal Use of Microcurrent Tools

For microcurrent facials to be effective, you'll need a device that delivers what it claims. EvenSkyn® Phoenix: Premium Face Lifting Microcurrent Bar is an ideal choice for massaging your face. This device offers consistent microcurrent along with a deep kneading massage. 

The best feature is the technology to charge from artificial light and solar rays. So you don't even need to charge it or replace the batteries. The device has a premium design with four alloy rollers at a 115° angle to deliver a deep kneading massage to the skin. This brings more blood circulation and firmness to the dermal tissues. 

In addition, you may use EvenSkyn® Conduction Gel for easy gliding of the microcurrent device. It contains ceramides and hyaluronic acid that hydrate and nourish activated skin tissues. Wash your face and neck and apply the gel before using the device. For best results, you may use the roller on your face and neck for 5-10 minutes in 24 hours. 

Wrapping Up

Now you know the science behind skin health and its rejuvenation process. Many aging signs, such as saggy skin, spots, fine lines, and wrinkles, may be targeted with microcurrent facial tools. With consistent use, you may achieve younger-looking, tighter skin. Since the device triggers collagen and elastin in the dermis, it enhances the facial tissue from within. 

The convenience of using this wand anytime and anywhere is a game changer. You may use it consistently on the go and not fret over scheduling regular spa visits. Besides this, consider a nutritional diet, a good skincare regime, and sun protection for glowing skin. 


  1. Llorenç Solé-Boldo, Günter Raddatz. "Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming." 2020
  2. Neelam A. Vashi Mayra Buainain De Castro Maymone. "Aging Differences in Ethnic Skin." 2016
  3. Llorenç Solé-Boldo, Günter Raddatz, Sabrina Schütz. "Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming." 2020
  4. Joseph D. Sherrill, Deborah Finlay. "Transcriptomic analysis of human skin wound healing and rejuvenation following ablative fractional laser treatment." 2021
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  6. Fatemeh Saniee, Hamid Reza. "Consider of Micro-Current's Effect to variation of Facial Wrinkle trend, Randomized Clinical Trial Study" 2012
  7. Hani Yousef; Mandy Alhajj; Sandeep Sharma. "Anatomy, Skin (Integument), Epidermis." 2022
  8. Victor Gabriel. "Perceived Age and Life Style. The Specific Contributions of Seven Factors Involved in Health and Beauty." 2017
  9. Katherine E. Westbrook. Trevor A. Nessel, Marc H. Hohman, Matthew Varacallo. "Anatomy, Head and Neck: Facial Muscles." 2022
  10. John D'Orazio, Stuart Jarrett. "UV Radiation and the Skin" 2013
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  12. Nicholas R Sinclair, Demetrius M Coombs. "How to Prevent and Treat Complications in Facelift Surgery, Part 1: Short-Term Complications" 2021

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